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Article

Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis.

Science immunology - 31 Oct 2025

Satoh Saya, Tan Yaw Bia, Heil Benjamin, Yamada Shintaro, Schütte Verena, Phang Celest, Tang Chaozhi, Tsukamoto Yuta, Higuchi Takahiro, Fujita Takashi, Behrendt Rayk, Schlee Martin, Luo Dahai, Kato Hiroki

Abstract excerpt

Detecting viral RNA by the ubiquitously expressed cytosolic receptor retinoic acid-inducible gene I (RIG-I) is critical for antiviral immune responses, including type I interferon (IFN-I) and chemokine induction. RIG-I has evolved to sensitively recognize viral RNA but tolerate self-RNA. RIG-I mutations causing self-tolerance loss induce IFN-I and chemokines in patients, initiating autoinflammation. We observed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41171879
DOI: 10.1126/sciimmunol.adx1135

Genes

CCR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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