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Article

Plasma extrachromosomal circular DNA as a biomarker in EGFR-targeted therapy of non-small cell lung cancer.

Molecular oncology - 1 Apr 2026

Stensgaard Simone, Mehmood Sarmad, Ebert Eva Boysen Fynboe, Meldgaard Peter, Dutta Anindya, Sorensen Boe S

Abstract excerpt

The genomic instability associated with cancer can result in the formation of extrachromosomal circular DNA (eccDNA), which contributes to tumor heterogeneity, gene amplification, tumor evolution, and drug resistance. However, most studies on eccDNA have been conducted on tumor tissue or cancer cell lines, and limited research has been done on eccDNA in plasma. In this study, we investigated eccDNA in non-small...

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Identifiers

PMID: 41165514
DOI: 10.1002/1878-0261.70138
PMCID: PMC13060643

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EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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