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Article

Phenotypic plasticity including drug efflux drives reversible irinotecan resistance in LIM1215 colorectal cancer cells.

FEBS letters - 1 Jan 2026

Dilber Tugce, Yalcin Gizem Damla, Yilmaz Kubra Celikbas, Acar Ahmet

Abstract excerpt

Colorectal cancer (CRC) presents significant therapeutic challenges, particularly due to the development of resistance to standard chemotherapeutic agents such as irinotecan. In this study, we aimed to investigate the molecular and phenotypic mechanisms underlying irinotecan resistance in CRC using the LIM1215 cell line model. Transcriptomic analysis demonstrated that drug withdrawal induced major transcriptional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41147609
DOI: 10.1002/1873-3468.70208

Genes

ABCB1
ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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