The role of HLA-E polymorphism and soluble HLA-E isoform in recurrent reproductive failures and male infertility.

doi:10.1016/j.imbio.2025.153130

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Article

The role of HLA-E polymorphism and soluble HLA-E isoform in recurrent reproductive failures and male infertility.

Immunobiology - 1 Nov 2025

Tarnowska Agnieszka, Wiśniewski Andrzej, Burnos Julia, Radwan Paweł, Chorobik Kazimierz, Radwan Michał, Piekarska Karolina, Malinowski Andrzej, Wilczyński Jacek R, Nowak Izabela

Abstract excerpt

BACKGROUND: Human leukocyte antigen (HLA)-E as a non-classical HLA class I molecule interacting with NK and T cell receptors may activate or inhibit immune responses. These reactions can impact reproductive success because HLA-E is expressed by trophoblast cells. In this study, we investigated rs1264457 A/G HLA-E polymorphism in couples with reproductive failures such as recurrent implantation failure (RIF) after...

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PMID: 41138607
DOI: 10.1016/j.imbio.2025.153130

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