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Colon cancer in Appalachian Kentucky: Unique genetic, microbiome and obesity findings in a cohort comparison.

HGG advances - 15 Jan 2026

Chow Zeta, Liu Jinpeng, He Daheng, Wang Chi, Gan Tong, Mansour Akila, Shaker Nuha, Dravillas Caroline, Hoyd Rebecca, Durbin Eric, Napier Dana, Gao Tianyan, Schaberg Kurt, Huang Lyen, Ulrich Neli, Siegel Erin, Edge Stephen, Cook Linda, Salhia Bodour, Churchman Michelle, Kolesar Jill, Spakowicz Daniel, Evers B Mark, Bocklage Therese

Abstract excerpt

We investigated colon cancer genomics and microenvironmental features in the Appalachian Kentucky population, a group with the highest incidence of colon cancer in the United States. We assessed two inter-related risk factors for colon cancer (obesity and abnormal gut bacterial microbiome) and their genetic associations within this population. To evaluate potential unique characteristics of the high-incidence...

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Identifiers

PMID: 41063459
DOI: 10.1016/j.xhgg.2025.100527
PMCID: PMC12554973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 12 Sept 2026.

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