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Distinct microbes, metabolites, and the host genome define the multi-omics profiles in right-sided and left-sided colon cancer

27 Dec 2024

Abstract excerpt

BACKGROUND: Studies have reported clinical heterogeneity between right-sided colon cancer (RCC) and left-sided colon cancer (LCC). However, none of these studies used multi-omics analysis combining genetic regulation, microbiota, and metabolites to explain the site-specific difference. METHODS: Here, 494 participants from a 16S rRNA gene sequencing cohort (50 RCC, 114 LCC, and 100 healthy controls) and a...

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PMID: 39731152
DOI: 10.1186/s40168-024-01987-7

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