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Article

Calcifying nested stromal-epithelial tumor of the liver: Report of two cases revealing novel WT1 mutation and distinct epigenetic features.

Virchows Archiv : an international journal of pathology - 1 Apr 2026

Strakova-Peterikova Andrea, Fedeli Franco, Rychly Boris, Soukup Jiri, Michal Michael, Martinek Petr, Grendar Marian, Mosaieby Elaheh, Ptakova Nikola, Slisarenko Maryna, Michal Michal, Michalova Kvetoslava

Abstract excerpt

Calcifying nested stromal-epithelial tumor (CNSET) is an extremely rare primary liver tumor of uncertain histogenesis that predominantly occurs in the pediatric age group and young adults. Knowledge regarding the molecular genetic profile of this entity remains limited, with only two molecular studies conducted to date, which identified pathogenic mutations in the CTNNB1 gene and TERT promoter mutations in all...

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Identifiers

PMID: 41062884
DOI: 10.1007/s00428-025-04281-5
PMCID: PMC13053525

Genes

WT1
CTNNB1
TERT
SPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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