Article
Development and Validation of Polygenic Scores for Retinal Vessel Calibers.
Investigative ophthalmology & visual science - 1 Oct 2025
Yu Chenglong, Rupasinghe Nuwanthi, Robman Liubov, Hodgson Lauren A B, Pham Thao, Woods Robyn L, Wolfe Rory, Ward Stephanie A, Abhayaratna Walter P, Guymer Robyn H, Robb Catherine, Fransquet Peter D, Lin Tian, Sim Xueling, Wong Tien Yin, MacGregor Stuart, McNeil John J, Lacaze Paul
Abstract excerpt
Purpose: Retinal vessel calibers are genetically heritable, quantitatively measured, and noninvasive ocular biomarkers of microvascular health. Despite their heritability identified from genome-wide association studies (GWASs), polygenic scores (PGSs) for these traits have not been developed. We aimed to calculate PGSs and associate them with retinal vessel caliber phenotypes in older adults. Methods: Our study...
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