Article
Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.
PLoS genetics - 28 Oct 2010
Ikram M Kamran, Sim Xueling, Xueling Sim, Jensen Richard A, Cotch Mary Frances, Hewitt Alex W, Ikram M Arfan, Wang Jie Jin, Klein Ronald, Klein Barbara E K, Breteler Monique M B, Cheung Ning, Liew Gerald, Mitchell Paul, Uitterlinden Andre G, Rivadeneira Fernando, Hofman Albert, de Jong Paulus T V M, van Duijn Cornelia M, Kao Linda, Cheng Ching-Yu, Smith Albert Vernon, Glazer Nicole L, Lumley Thomas, McKnight Barbara, Psaty Bruce M, Jonasson Fridbert, Eiriksdottir Gudny, Aspelund Thor, Harris Tamara B, Launer Lenore J, Taylor Kent D, Li Xiaohui, Iyengar Sudha K, Xi Quansheng, Sivakumaran Theru A, Mackey David A, Macgregor Stuart, Martin Nicholas G, Young Terri L, Bis Josh C, Wiggins Kerri L, Heckbert Susan R, Hammond Christopher J, Andrew Toby, Fahy Samantha, Attia John, Holliday Elizabeth G, Scott Rodney J, Islam F M Amirul, Rotter Jerome I, McAuley Annie K, Boerwinkle Eric, Tai E Shyong, Gudnason Vilmundur, Siscovick David S, Vingerling Johannes R, Wong Tien Y
Abstract excerpt
There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery...
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