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Article

RISING STARS: Effects of a GLP-1 receptor polymorphism on responses to liraglutide.

The Journal of endocrinology - 1 Oct 2025

Mashayekhi Mona, Safa Bilgunay Ilkin, Nian Hui, Devin Jessica K, Gamboa Jorge L, Yu Chang, Chen Rui, Beckman Joshua A, Koethe John R, Silver Heidi J, Niswender Kevin, Luther James M, Brown Nancy J

Abstract excerpt

Abstract: The rs6923761 (Gly168Ser) missense variant in the glucagon-like peptide-1 receptor (GLP-1R) has been associated with favorable anthropometric and metabolic parameters in individuals with obesity but decreased responsiveness to incretin-based therapies. Here, we performed a pre-specified analysis of a randomized-controlled trial in individuals with obesity and pre-diabetes comparing treatment with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41042549
DOI: 10.1530/JOE-25-0174
PMCID: PMC12556785

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