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Article

Cutting edge: Extrinsic and intrinsic sex effects differentially regulate pulmonary ILC2 numbers, phenotype, and function.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2025

Williams Abigael P, Turner Sean, Chlebicz Magdalena, Carter Hannah, Miller Reegan A J, Allushi Bujana, Roe Mandi M, Mejia Laura Loriel, Labombarde Jocelyn, Alberola-Ila José, Kovats Susan

Abstract excerpt

Pulmonary type 2 innate lymphocytes (ILC2s) show sex dimorphism in numbers, phenotype, and function. We used a novel strategy of competitive, mixed male-female donor bone marrow chimeras to determine if sex differences in murine ILC2s result from extrinsic factors in the recipient environment or from durable intrinsic variables in donor cells. We show that the recipient sex environment regulated ILC2 numbers and...

Topics

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Immunity, Innate
Interleukin-5
Lectins, C-Type
Lung
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Orthomyxoviridae Infections

Receptors, Immunologic

Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 40489769
DOI: 10.1093/jimmun/vkaf114
PMCID: PMC12394977

Genes

KLRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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