Article
A fixed mutation in the respiratory complex I impairs mitochondrial bioenergetics in the endangered Apennine brown bear.
Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2025
Trucchi Emiliano, Fuselli Silvia, Perta Nunzio, Patergnani Simone, Danese Alberto, Balestra Dario, Capriotti Emidio, Di Muccio Giovanni, Di Marino Daniele, Pinton Paolo, Bertorelle Giorgio
Abstract excerpt
Effective conservation genomics of endangered species requires realistic understanding of the fitness consequences caused by the accumulation of deleterious mutations in declining populations. We experimentally investigated three mutations which have been bioinformatically predicted to be deleterious in the mitochondrial ND5 subunit of respiratory complex I and are fixed in the Apennine brown bear, an inbred...
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