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Article

Gut microbial genetic variations are associated with exploratory behavior via SNV-driven metabolic regulation in a sheep model.

Science China. Life sciences - 1 Jun 2026

Yang Shuai, Ma Beining, Gao Mengke, Wu Jiahua, Pilling Dale, Zhu Lin, Wang Xiuchao, Dong Quanbin, Wang Yifeng, Pool Kelsey, Maloney Shane, Li Peng, Blache Dominique, Ding Luoyang, Chen Lianmin

Abstract excerpt

Host neurocognitive functions are influenced by the gut microbiome, but the role of microbial genetic variation in shaping host neural behavior remains unexplored. Here, we profiled multi-omics data and neurobehavioral phenotypes in a model of 200 Merino sheep. Genomic reconstruction of deeply sequenced fecal and ruminal samples generated 5,253 species-level metagenomic-assembled genomes, of which 3,548 were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 40999305
DOI: 10.1007/s11427-025-3043-5

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