Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group.

doi:10.1038/s41380-025-03271-y

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Article

Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group.

Molecular psychiatry - 1 Dec 2025

Colbert Sarah M C, Monson Eric T, Andreassen Ole A, Ayinde Olatunde O, Barr Peter B, Bejan Cosmin A, Ceja Zuriel, Coon Hilary, DiBlasi Emily, Edenberg Howard J, Gelernter Joel, Hatoum Alexander, Izotova Anastasia, Johnson Emma C, Kaufman Erin A, Kranzler Henry R, Koromina Maria, Lehto Kelli, Myung Woojae, Nurnberger John I, Serretti Alessandro, Smoller Jordan W, Stein Murray B, Zai Clement C, Erlangsen Annette, Gaine Marie, Martorell Lourdes, Sud Reeteka, Toma Claudio, Bigdeli Tim B, Kimbrel Nathan A, Ruderfer Douglas, Docherty Anna R, Mann J John, Mullins Niamh

Abstract excerpt

Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overlap with each other and with related self-harm phenotypes, and varying associations with psychiatric disorders. GWAS have uncovered several loci associated with suicidality...

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PMID: 40999039
DOI: 10.1038/s41380-025-03271-y
PMCID: PMC12602352

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