Article
Establishment of a potential reference measurement procedure and reference material for PIK3CA H1047R mutation detection.
Analytical methods : advancing methods and applications - 9 Oct 2025
Wang Shangjun, Ji Hongmei, Jia Yuqian, Huang Bei, Dong Haijiao, Liu Ziyue, Xie Zhuoying, Sun Jie, Qian Jiayi, Gu Zhongze
Abstract excerpt
PIK3CA gene mutation is a promising predictor for many different human cancers, especially for breast cancer. Increasing numbers of non-invasive methods have been developed for the detection of PIK3CA mutations. However, a lack of reference measurement procedures (RMPs) and reference materials (RMs) impedes the consistency and comparability of test results in clinical practice. In this study, a potential RMP...
Topics
- Mutation
- Breast Neoplasms
- Humans
- Female
- Polymerase Chain Reaction
- Limit of Detection
- DNA Mutational Analysis
- Class I Phosphatidylinositol 3-Kinases