Lineage specification into GABAergic, glutamatergic, dopaminergic, and astrocytic phenotypes using MUSE stem cells: a novel approach for modeling neurodegenerative and psychiatric disorders.

Abstract excerpt

The study of neurodegenerative and psychiatric disorders is often hampered by the limited accessibility of relevant neural tissues and the limitations of existing in vitro models. MUSE cells (Multilineage differentiating stress enduring), which are non-tumorigenic and stress-resistant stem cells, offer a robust alternative to traditional models such as induced pluripotent stem cells (iPSCs), which suffer from...

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