Target antigen and plasma cell phenotype are critical factors for sensitivity to response-adapted daratumumab therapy.

doi:10.1182/blood.2025029921

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Article

Target antigen and plasma cell phenotype are critical factors for sensitivity to response-adapted daratumumab therapy.

Blood - 29 Jan 2026

Meads Mark B, Zhao Xiaohong, Noyes David, Sudalagunta Praneeth R, Achille Alexandra, Zhang Chaomei, Canevarolo Rafael R, Silva Maria, Magaletti Dario, DeAvila Daniel, Toska Sonila, Oates Ashley, Lastorino Daniel, Idiaquez Dietrich Werner, Song Jinming, Sansil Samer S, Yoder Sean J, Grajales-Cruz Ariel F, Blue Brandon, Freeman Ciara L, Kim Jongphil, Alsina Melissa, Brayer Jason, Silva Ariosto S, Song Xiaofei, Shain Kenneth H, Baz Rachid

Abstract excerpt

ABSTRACT: In this response-adapted clinic trial with daratumumab monotherapy for older patients with newly diagnosed multiple myeloma (MM), we identified target antigen expression, a plasma cell phenotype, and an activated immune tumor microenvironment (iTME) as critical features associated with response to CD38 monoclonal antibody therapy. Here, patients achieving a partial response after 2 cycles continued...

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Identifiers

PMID: 40983035
DOI: 10.1182/blood.2025029921

Genes

CD38
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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