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Genetic Variants Related to TGF-β Signaling Pathway Modulate Risk of Meniscus Injury: A Multiancestry Genome-wide Association Study.

Clinical orthopaedics and related research - 1 Jan 2026

Umesh Amith, Cordogan Stephan, Simpson Shae K, Bram Joshua T, Jones Ruth H, Schairer William W, Sboner Andrea, Elemento Olivier, Green Daniel W, Fabricant Peter D

Abstract excerpt

BACKGROUND: Numerous clinical risk factors and moderate heritability have been reported for meniscus injury. However, the genetic etiology of meniscus injury remains understudied. This study was a multiancestry genome-wide association study (GWAS) of meniscus injury aimed at identifying genomic variants that influence risk and elucidating the mechanisms by which they may exert their effects. QUESTIONS/PURPOSES:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40971882
DOI: 10.1097/CORR.0000000000003679

Genes

BMP6
UQCC1
EGR2
GDF5
MMP24
CAPZB
SMG6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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