In silico analysis of SH3BP2 genomic alterations and expression profiles in CRC.

Abstract excerpt

AIM: Colorectal cancer (CRC) is a widespread health issue that attains high mortality. The adaptor protein SH3BP2 amplification results in metabolic changes, oxidative stress, NK cell activity, and inflammation. The NK cells are capable of destroying tumor cells without prior activation, help prevent metastasis, and have prognostic value. Targeting SH3BP2 to regulate NK cell activity in the TME could enhance...

Topics

• Humans
• Adaptor Proteins, Signal Transducing
• Colorectal Neoplasms
• Gene Expression Regulation, Neoplastic
• Gene Expression Profiling
• Killer Cells, Natural