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Article

KALRN mutations promote antitumor immunity and immunotherapy response in cancer.

Journal for immunotherapy of cancer - 1 Oct 2020

Li Mengyuan, Ma Yuxiang, Zhong You, Liu Qian, Chen Canping, Qiang Lei, Wang Xiaosheng

Abstract excerpt

BACKGROUND: kalirin RhoGEF kinase (KALRN) is mutated in a wide range of cancers. Nevertheless, the association between KALRN mutations and the pathogenesis of cancer remains unexplored. Identification of biomarkers for cancer immunotherapy response is crucial because immunotherapies only show beneficial effects in a subset of patients with cancer. METHODS: We explored the correlation between KALRN mutations and...

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Identifiers

PMID: 33037113
DOI: 10.1136/jitc-2019-000293
PMCID: PMC7549479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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