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Article

Integrative Mendelian randomization for detecting exposure-by-group interactions using group-specific and combined summary statistics.

PLoS genetics - 1 Sept 2025

Xu Ke, Maydanchik Nathaniel, Kang Bowei, Chen Jianhai, Chen Qixiang, Xu Gongyao, Tasaki Shinya, Bennett David A, Chen Lin S

Abstract excerpt

Interactions between risk factors and covariate-defined groups are commonly observed in complex diseases. Existing methods for detecting interactions typically require individual-level data. The data availability and the measurements of risk exposures and covariates often limit the power and applicability in assessing interactions. To address these limitations, we propose int2MR, an integrative Mendelian...

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PMID: 40934263
DOI: 10.1371/journal.pgen.1011819
PMCID: PMC12440225

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