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Enigmatic Roles of Complement Anaphylatoxin Signaling in Health and Disease

1 Jan 2025

Abstract excerpt

Complement anaphylatoxins C3a and C5a are potent immunomodulators whose impact extends well beyond their traditional roles in innate immunity. Acting through G protein-coupled receptors C3aR, C5aR1, and C5aR2, these peptides take part in coordinating immune cell recruitment, vascular tone, and tissue remodeling. Yet their functions are deeply context-dependent: while they play essential roles in microbial...

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PMID: 40917792
DOI: 10.4110/in.2025.25.e32

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