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Article

Human length telomeres restrict the regenerative potential of hematopoietic stem cells in mice

24 Jul 2026

Abstract excerpt

Abstract Extremely short telomeres cause bone marrow failure in telomere biology disorder (TBDs) patients. Here, we employed the recently developed ‘Telomouse’ with human-length telomeres resulting from a single amino acid substitution in the helicase Rtel1 ( Rtel1 M492K/M492K ) to determine the effects of the short telomeres on the bone marrow and hematopoiesis. Under homeostatic conditions, Telomice have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40909680
DOI: 10.1016/j.jbc.2026.113364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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