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Article

Bacterial cell widening alters periplasmic size and activates envelope stress responses.

The EMBO journal - 1 Oct 2025

Zietek Matylda, Miguel Amanda, Shi Handuo, Khusainov Iskander, Asmar Abir T, Ram Sri, Wartel Morgane, Sueki Anna, Schorb Martin, Goulian Mark, Collet Jean-François, Beck Martin, Huang Kerwyn Casey, Typas Athanasios

Abstract excerpt

The Rcs signal transduction system is a phosphorelay responsible for sensing enterobacterial cell envelope stresses. In Escherichia coli, the Rcs system is required to survive treatment with A22 and mecillinam, antibiotics that perturb cell size. To test whether size changes are correlated with envelope damage and thereby sensed by the Rcs system, we tuned E. coli cell size via A22 treatment, mutations in the...

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Identifiers

PMID: 40903550
DOI: 10.1038/s44318-025-00534-w
PMCID: PMC12528386

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