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Article

Mepolizumab alters gene regulatory networks of nasal airway type-2 and epithelial inflammation in urban children with asthma

2 Sept 2025

Abstract excerpt

Mepolizumab (anti-IL5 therapy) reduces asthma exacerbations in urban children with exacerbation-prone eosinophilic asthma. We previously utilized nasal transcriptomics to identify inflammatory pathways (gene co-expression modules) associated with asthma exacerbations despite this therapy. In this study, we applied differential gene correlation analysis on these targeted gene co-expression modules to gain better...

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PMID: 40897727
DOI: 10.1038/s41467-025-63629-2

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