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Enhancing HIV Genotyping and Drug-Resistance Detection in Low Viral Load Samples Through Exosome Enrichment Technology.

AIDS research and human retroviruses - 1 Nov 2025

Peng Jun, Song Yebin, Chen Zhong, Xu Lei, Guo Lei, Xie Xiaoxin, Fu Yanhua, Long Hai, Feng Yanmeng, He Kai

Abstract excerpt

Genotypic drug-resistance testing for HIV-1 with low viral loads (VLs) (<1,000 copies/mL) is clinically important but technically challenging. Due to the overlapping physical size characteristics of HIV-1 viral particles (100-120 nm) and exosomes (40-150 nm), simultaneous enrichment of both using size separation technology may offer a new strategy to improve the success rate of genotypic resistance testing in low...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40892485
DOI: 10.1177/08892229251374705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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