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Article

Selective TLR ligand stimulation enhances in vivo mosquito-borne flavivirus pathogenicity

29 Aug 2025

Abstract excerpt

Mosquito saliva facilitates pathogen transmission and enhances the severity of diseases caused by mosquito-borne viruses; however, the underlying mechanisms are unknown. Here, we demonstrate that mosquito salivary gland extracts (SGEs) enhance flaviviral pathogenicity in vivo by activating innate immune responses following the accumulation of immune cells at the infection site. Among the innate immune signaling...

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PMID: 40886313
DOI: 10.1016/j.celrep.2025.116210

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