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Mosquito Saliva Serine Protease Enhances Dissemination of Dengue Virus into the Mammalian Host

17 Oct 2013

Abstract excerpt

Dengue virus (DENV), a flavivirus of global importance, is transmitted to humans by mosquitoes. In this study, we developed in vitro and in vivo models of saliva-mediated enhancement of DENV infectivity. Serine protease activity in Aedes aegypti saliva augmented virus infectivity in vitro by proteolyzing extracellular matrix proteins, thereby increasing viral attachment to heparan sulfate proteoglycans and...

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PMID: 24131723
DOI: 10.1128/jvi.02235-13

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