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Article

Flaviviruses Produce a Subgenomic Flaviviral RNA That Enhances Mosquito Transmission

18 Dec 2017

Abstract excerpt

Mosquito-borne flaviviruses (MBFVs) are a global public health burden. MBFVs have several unique 3'UTR structures that inhibit the host RNA decay machinery to produce subgenomic flaviviral RNAs (sfRNAs). Number of sfRNA species and their relative quantities are dependent on the 3'UTR tertiary structures and can vary between tissues. Two recent in vivo studies demonstrated that sfRNA enhances mosquito...

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PMID: 29251994
DOI: 10.1089/dna.2017.4059

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