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Article

Haptoglobin phenotypes and structural variants associate with post-exertional malaise and cognitive dysfunction in myalgic encephalomyelitis.

Journal of translational medicine - 28 Aug 2025

Moezzi Atefeh, Ushenkina Anastasiya, Widgren Anna, Bergquist Jonas, Li Peng, Xiao Wenzhong, Rostami-Afshari Bita, Leveau Corinne, Elremaly Wesam, Caraus Iurie, Franco Anita, Godbout Christian, Nepotchatykh Oleg, Moreau Alain

Abstract excerpt

BACKGROUND: Myalgic encephalomyelitis (ME) is a chronic, multisystem illness characterized by post-exertional malaise (PEM) and cognitive dysfunction, yet the molecular mechanisms driving these hallmark symptoms remain unclear. This study investigated haptoglobin (Hp) as a potential biomarker of PEM severity and cognitive impairment in ME, with a focus on Hp phenotypes and structural proteoforms. METHODS: A...

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Identifiers

PMID: 40877900
DOI: 10.1186/s12967-025-07006-z
PMCID: PMC12395708

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