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Article

Alterations in ether lipid metabolism in obesity revealed by systems genomics of multi-omics datasets.

PLoS biology - 1 Aug 2025

Schooneveldt Yvette L, Paul Sudip, Huynh Kevin, Beyene Habtamu B, Mellett Nat A, Watts Gerald F, Hung Joseph, Hui Jennie, Beilby John, Blangero John, Moses Eric K, Shaw Jonathan E, Magliano Dianna J, Seldin Marcus M, Drew Brian G, Calkin Anna C, Giles Corey, Meikle Peter J

Abstract excerpt

Ratios between two metabolites are sensitive indicators of metabolic changes. Lipidomic profiling studies have revealed that plasma ether lipids, a class of glycero- and glycerophospho-lipids with reported health benefits, are negatively associated with obesity. Here, we utilized lipid ratios as surrogate markers of lipid metabolism to explore the processes underlying the inverse relationship between ether lipid...

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Identifiers

PMID: 40875616
DOI: 10.1371/journal.pbio.3003349
PMCID: PMC12393746

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TMEM229B

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