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Homologous and Heterologous Vaccination Regimens with mRNA and rVSV Platforms Induce Potent Immune Responses Against SFTSV Glycoprotein

8 Aug 2025

Abstract excerpt

BACKGROUND: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly pathogenic bunyavirus with a high case-fatality ratio for which there is no approved vaccine. Studies have assessed different vaccine technologies. However, few studies have yet assessed the immunogenicity of heterologous prime-boost regimens. METHODS: Here, we compare a lipid nanoparticle (LNP)-encapsulated nucleoside-modified...

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PMID: 40872809
DOI: 10.3390/v17081095

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