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Abnormalities of the corpus callosum in non-psychotic high-risk offspring of schizophrenia patients

10 Dec 2010

Abstract excerpt

Alterations in the structure of the corpus callosum (CC) have been observed in schizophrenia. Offspring of schizophrenia parents have 10-15 times higher risk for developing schizophrenia. We examined CC volume in offspring at genetic high-risk (HR) subjects. Since the sub-regions of the CC are topographically mapped to cortical brain regions, we hypothesized that HR subjects may show a decrement in total volume...

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PMID: 21145214
DOI: 10.1016/j.pscychresns.2010.09.007

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