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Rewiring Aromatic Compound Consumption: Chromosomal Amplification and Evolution of a Foreign Pathway in Acinetobacter baylyi ADP1.

ACS synthetic biology - 19 Sept 2025

Baugh Alyssa C, Tumen-Velasquez Melissa P, Zempel Isabella R, Duscent-Maitland Chantel V, Slarks Lauren E, Defalco Justin B, Johnson Christopher W, Beckham Gregg T, Neidle Ellen L

Abstract excerpt

Rational engineering strategies that seek to harness the remarkable diversity of microbial metabolism can be limited by incomplete biological knowledge. As described here, a novel approach to address this challenge involved replacing a native pathway for degrading lignin-derived aromatic compounds via ortho cleavage of protocatechuate in Acinetobacter baylyi ADP1 with a foreign meta-cleavage pathway that uses...

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PMID: 40864971
DOI: 10.1021/acssynbio.5c00341
PMCID: PMC12455638

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