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Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model

25 Apr 2024

Abstract excerpt

OBJECTIVE: To characterize aspects of triiodothyronine (T3) induced chondrocyte terminal maturation within the molecular osteoarthritis pathophysiology using the previously established T3 human ex vivo osteochondral explant model. DESIGNS: RNA-sequencing was performed on explant cartilage obtained from OA patients (n = 8), that was cultured ex vivo with or without T3 (10 ng/ml), and main findings were validated...

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PMID: 38664820
DOI: 10.1186/s13075-024-03326-5

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