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The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment

23 Jul 2025

Abstract excerpt

Cryptosporidium is a leading cause of diarrheal disease, yet little is known regarding the infection cell biology of this intracellular intestinal parasite. To this end, we implemented an arrayed genome-wide CRISPR-Cas9 knockout screen to microscopically analyze multiple phenotypic features of a Cryptosporidium infection following individual host gene ablation. We discovered parasite survival within the host...

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PMID: 40706591
DOI: 10.1016/j.cell.2025.07.001

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