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Article

SLC6A3 gene methylation may be associated with alcohol use disorder, but personality and life stress may not influence methylation.

CNS spectrums - 15 Aug 2025

Chyou Te-En, Kuo Shin-Chang, Yeh Yi-Wei, Chen Chun-Yen, Lin Chun-Long, Huang Chih-Yun, Lee Shin-Min, Huang San-Yuan

Abstract excerpt

BACKGROUND: DNA methylation plays a crucial role in gene regulation and has been implicated in various neuropsychiatric disorders, including alcohol use disorder (AUD). The rs27072 polymorphism within the SLC6A3 gene has been studied in addictive disorders; however, its role in epigenetic modifications remains unclear. This study investigates the methylation levels of CpG sites near rs27072 and their potential...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Alcoholism
Share to CpG Islands
Share to DNA Methylation
Share to Dopamine Plasma Membrane Transport Proteins
Share to Epigenesis, Genetic
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Share to Polymorphism, Single Nucleotide
Share to Stress, Psychological

Source

Open in PubMed Open full text

Identifiers

PMID: 40814263
DOI: 10.1017/S1092852925100473
PMCID: PMC13064777

Genes

SLC6A3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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