Article
SLC6A3 gene methylation may be associated with alcohol use disorder, but personality and life stress may not influence methylation.
CNS spectrums - 15 Aug 2025
Chyou Te-En, Kuo Shin-Chang, Yeh Yi-Wei, Chen Chun-Yen, Lin Chun-Long, Huang Chih-Yun, Lee Shin-Min, Huang San-Yuan
Abstract excerpt
BACKGROUND: DNA methylation plays a crucial role in gene regulation and has been implicated in various neuropsychiatric disorders, including alcohol use disorder (AUD). The rs27072 polymorphism within the SLC6A3 gene has been studied in addictive disorders; however, its role in epigenetic modific...
Topics
- Humans
- Male
- DNA Methylation
- Stress, Psychological
- Adult
- Alcoholism
- Personality
- Middle Aged
- Epigenesis, Genetic
- CpG Islands
- Polymorphism, Single Nucleotide
- Dopamine Plasma Membrane Transport Proteins