Artemisinin Partial Resistance Mutations in Zanzibar and Tanzania Suggest Regional Spread and African Origins, 2023.

doi:10.1093/infdis/jiaf431

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Article

Artemisinin Partial Resistance Mutations in Zanzibar and Tanzania Suggest Regional Spread and African Origins, 2023.

The Journal of infectious diseases - 18 Feb 2026

Connelly Sean V, Muller Julia G, Ali Mohamed, Ngasala Billy E, Hassan Wahida, Mohamed Bakari, Thwai Kyaw L, Sadler Jacob M, Marglous Jacob, Fola Abebe A, Zacharia Abdallah, Shija Shija J, Mohammed Safia, C Msolo Dominick, Said Hamza, Peter Editruda E, Odas Melic, Rutha Isaack J, Nwange Mwanaidi, Naire Karamoko, Ruybal-Pesántez Shazia, Verity Robert, Crudale Rebecca, Goel Varun, Choloi Barbara B, Björkman Anders, Bailey Jeffrey A, Lin Jessica T, Juliano Jonathan J

Abstract excerpt

Artemisinin partial resistance, driven by Plasmodium falciparum K13 mutations, threatens malaria control. Zanzibar is vulnerable to artemisinin partial resistance spread but lacks recent molecular surveillance. We sequenced samples in Zanzibar and mainland Tanzania collected from 2022 to 2024. K13 mutations were found in 2 of 1440 participants (P441L, A675V) in Zanzibar and 6 of 3762 (R561H, P441L) in mainland...

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PMID: 40802860
DOI: 10.1093/infdis/jiaf431
PMCID: PMC13017645

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