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Article

Pan-cancer landscape of basement membrane: multi-omics research and single-cell sequencing validation.

Cell cycle (Georgetown, Tex.) - 1 Jan 2025

Tang Yi, Zhang Qiuhuan, Yuan Zhuoer, Yin De, Zhang Shengyue, Sun Yucao, Mo Chong-de, Tang Zhenyong, Zhao Jiehua, Tang Yuntian

Abstract excerpt

Epithelial carcinoma cells require penetration of the basement membrane (BM) to metastasize. The BM is a thin layer of extracellular matrix beneath epithelial and endothelial tissues. It acts as a structural barrier, preventing cancer cells from invading and undergoing endocytosis and exocytosis. Thus, understanding the relationship between the BM and tumor immunity can lead to new strategies for halting cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40799172
DOI: 10.1080/15384101.2025.2539645
PMCID: PMC12427506

Genes

CD276
NRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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