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Detection of genome-wide methylation changes in bladder cancer by long-read sequencing of urinary DNA

11 Aug 2025

Abstract excerpt

BACKGROUND: Non-invasive urine tests for bladder cancer (BC) could reduce dependence on flexible cystoscopy for diagnosis and surveillance. Most recent developments in urine testing are based on targeted detection of genomic and/or epigenomic markers. We hypothesised that long-read whole-genome sequencing of urinary DNA with direct methylation profiling may allow accurate BC detection and insights into disease...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 40790606
DOI: 10.1186/s13148-025-01946-5

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