Host–Microbe Multiomic Profiling Predicts Mortality in Sepsis

Abstract excerpt

RATIONALE: Sepsis is a leading cause of mortality and involves a dysregulated host response to infection. The host and microbe have historically been considered independently in studies of sepsis, limiting our understanding of key relationships driving mortality. OBJECTIVES: We sought to identify host and microbial factors associated with sepsis mortality and build prognostic classifiers. METHODS: We studied 321...

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