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Article

The rs11150601 Intron Variant of SETD1A Is Associated With Female Schizophrenia in the UK Biobank Cohort.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2026

Lehrer Steven, Rheinstein Peter H

Abstract excerpt

Schizophrenia is a complex psychiatric disorder with an estimated heritability of 80%. SETD1A, a gene encoding a histone methyltransferase critical for transcriptional regulation, has been identified as a significant risk factor for schizophrenia. Loss-of-function mutations in SETD1A confer up to a 35-fold increased risk, implicating its role in neurodevelopment and synaptic plasticity. Using data from the UK...

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Identifiers

PMID: 40787707
DOI: 10.1002/ajmg.b.33054

Genes

SETD1A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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