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Article

Effects of sphingolipid metabolism related genes-SPTLC1, ORMDL3, SPHK1 and S1PR3 polymorphisms on susceptibility to hashimoto's thyroiditis.

Journal of endocrinological investigation - 1 Nov 2025

Li Xin, Zhao Haixia, Xiao Zhifu

Abstract excerpt

BACKGROUND: The destruction of thyroid follicles is an important morphological manifestation of Hashimoto's thyroiditis (HT), and sphingolipid (SPL) metabolism is crucial for maintaining the homeostasis of membrane lipid composition and the stability of the cell membrane. Therefore, the pathogenesis of HT may be related to SPL metabolism. This study aimed to evaluate the associations between SPL metabolism...

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Source

Identifiers

PMID: 40782218
DOI: 10.1007/s40618-025-02666-6

Genes

ORMDL3
S1PR3
SPHK1
SPTLC1
S1PR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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