Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated single-cell and transcriptomic analysis of bone marrow-derived metastatic neuroblastoma reveals molecular mechanisms of metabolic reprogramming

5 Aug 2025

Abstract excerpt

Neuroblastoma (NB) is the most common extracranial solid tumor in early childhood and frequently presents with bone marrow (BM) metastasis, particularly in high-risk cases. Metastatic NB cells residing in the BM exhibit distinct biological behaviors and are closely associated with treatment resistance and poor prognosis. Emerging evidence suggests that metabolic reprogramming is a hallmark of NB progression;...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Immune cells in cancer
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40764361
DOI: 10.1038/s41598-025-13626-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated single-cell and transcriptomic analysis of bone marrow-derived metastatic neuroblastoma reveals molecular mechanisms of metabolic reprogrammingPMID 40764361Read ↗

Combined analysis of RNA-sequence and microarray data reveals effective metabolism-based prognostic signature for neuroblastoma.Semantic proximity Read ↗

Metabolism and Tumor Microenvironment-Associated Molecular Classification of NeuroblastomaSemantic proximity Read ↗

Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progressionSemantic proximity Read ↗

Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiringSemantic proximity Read ↗

NBAtlas: A harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumorsSemantic proximity Read ↗

A prognostic metabolism-related gene signature associated with the tumor immune microenvironment in neuroblastomaSemantic proximity Read ↗

MYCN Amplifications and Metabolic Rewiring in NeuroblastomaSemantic proximity Read ↗

Single-Cell Atlas Identifies TUBB2B+ Epithelial Subpopulations as Hubs of Methionine Metabolism in Nasopharyngeal CarcinomaSemantic proximity Read ↗

Identification of prognostic biomarkers in neuroblastoma using WGCNA and multi-omics analysisSemantic proximity Read ↗

Joint analysis of the metabolomics and transcriptomics uncovers the dysregulated network and develops the diagnostic model of high-risk neuroblastomaSemantic proximity Read ↗

Identifying metabolic reprogramming phenotypes with glycolysis-lipid metabolism discoordination and intercellular communication for lung adenocarcinoma metastasis.Semantic proximity Read ↗

Single-cell RNA sequencing reveals route-specific remodeling of the tumor microenvironment and identifies predictive factors of breast cancer metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.