Article
Combined analysis of RNA-sequence and microarray data reveals effective metabolism-based prognostic signature for neuroblastoma.
Journal of cellular and molecular medicine - 1 Sept 2020
Meng Xinyao, Feng Chenzhao, Fang Erhu, Feng Jiexiong, Zhao Xiang
Abstract excerpt
The relationship between metabolism reprogramming and neuroblastoma (NB) is largely unknown. In this study, one RNA-sequence data set (n = 153) was used as discovery cohort and two microarray data sets (n = 498 and n = 223) were used as validation cohorts. Differentially expressed metabolic genes were identified by comparing stage 4s and stage 4 NBs. Twelve metabolic genes were selected by LASSO regression...
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