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Article

Excessive ultra-processed foods exposure aggravates ulcerative colitis via macrophage ferroptosis

29 Jul 2025

Abstract excerpt

, and reactive oxygen species (ROS) with statistical significance (p < 0.05). Crucially, ALKBH5 overexpression restored GCLM-mediated antioxidant defenses and mitigated ferroptosis in RAW264.7 cells (p < 0.05). Immunofluorescence confirmed KS-mediated suppression of the ALKBH5-GCLM axis in clinical specimens, exhibiting strong correlation with UC (p < 0.05). Our findings establish UPFs-derived KS as a novel...

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PMID: 40749542
DOI: 10.1016/j.envint.2025.109706

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