Article

ATG5-mediated keratinocyte ferroptosis promotes M1 polarization of macrophages to aggravate UVB-induced skin inflammation

2024-01-30

Abstract excerpt

<title>Abstract</title> <p>Autophagy participates in the regulation of ferroptosis. Among numerous autophagy-related genes (ATGs), ATG5 plays a pivotal role in ferroptosis. However, how ATG5-mediated ferroptosis functions in UVB-induced skin inflammation is still unclear. In this study, we confirm that the core ferroptosis inhibitor GPX4 is significantly decreased in human skin tissue exposed to sunlight. We repo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 964e5902-b141-52a4-8c64-12b55fcaa755
DOI: 10.21203/rs.3.rs-3738648/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ATG5-mediated keratinocyte ferroptosis promotes M1 polarization of macrophages to aggravate UVB-induced skin inflammationDOI 10.21203/rs.3.rs-3738648/v1Read

Investigating potential ferroptosis‐related differentially expressed genes of UVB ‐induced skin photodamageSemantic proximity Read

Autophagy: Multiple Mechanisms to Protect Skin from Ultraviolet Radiation-Driven PhotoagingSemantic proximity Read

Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesisSemantic proximity Read

The signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseasesSemantic proximity Read

Autophagy: Guardian of Skin BarrierSemantic proximity Read

Pilot study of the role of ferroptosis in abnormal biological behaviour of keratinocytes in psoriasis vulgarisSemantic proximity Read

Unveiling ferroptosis: a new frontier in skin disease researchSemantic proximity Read

The multifaceted role of autophagy in skin autoimmune disorders: a guardian or culprit?Semantic proximity Read

Mechanisms of autophagy and their implications in dermatological disordersSemantic proximity Read

Effect of Sun exposure-induced ferroptosis mechanisms on pathology and potential biological processes of primary melanoma by microarray data analysisSemantic proximity Read

Narrow-band UVB radiation triggers diverse changes in the gene expression and induces the accumulation of M1 macrophages in human skinSemantic proximity Read

Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based PhototherapySemantic proximity Read