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Molecular mechanisms of ferroptosis in ulcerative colitis: insights from machine learning, WGCNA, and immune cell infiltration analysis

29 Aug 2025

Abstract excerpt

Background This study aimed to investigate ferroptosis-related biomarkers and their potential molecular basis in UC. Methods UC datasets (GSE87466 and GSE47908) from the Gene Expression Omnibus database were merged as the training set, and batch effects were removed. Ferroptosis-related differentially expressed genes (DE-FRGs) were selected to construct a diagnostic risk model in UC. Machine learning (lasso...

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PMID: 40948782
DOI: 10.3389/fimmu.2025.1615186

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