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Article

Evaluation of pandemic potential of the genotype 4 (G4) swine influenza virus using ex vivo and in vitro cultures of the human respiratory tract.

The Journal of general virology - 1 Jul 2025

Chan Jenny C M, Ching Rachel H H, Kock Hermione H M, Long Teng, Nicholls John M, Peiris J S Malik, Hui Kenrie P Y, Chan Michael C W

Abstract excerpt

Recent studies have reported a genotype 4 (G4) reassortant Eurasian avian-like (EA) H1N1 virus in swine, demonstrating a potential pandemic threat in humans. Here, we have compared the tropism, replication competence and pro-inflammatory cytokine and chemokine induction of the two G4 EA H1N1 strains in parallel with 2009 pandemic H1N1 (H1N1/pdm/09) and A/Quail/HK/G1/1997 H9N2 (G1) using ex vivo culture of the...

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Identifiers

PMID: 40742730
DOI: 10.1099/jgv.0.002133
PMCID: PMC12313140

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