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Article

Evaluation of the human adaptation of influenza A/H7N9 virus in PB2 protein using human and swine respiratory tract explant cultures.

Scientific reports - 14 Oct 2016

Chan Louisa L Y, Bui Christine T H, Mok Chris K P, Ng Mandy M T, Nicholls John M, Peiris J S Malik, Chan Michael C W, Chan Renee W Y

Abstract excerpt

Novel avian H7N9 virus emerged in China in 2013 resulting in a case fatality rate of around 39% and continues to pose zoonotic and pandemic risk. Amino acid substitutions in PB2 protein were shown to influence the pathogenicity and transmissibility of H7N9 following experimental infection of ferrets and mice. In this study, we evaluated the role of amino acid substitution PB2-627K or compensatory changes at...

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Identifiers

PMID: 27739468
DOI: 10.1038/srep35401
PMCID: PMC5064379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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